Which installtion system is the best today to create advanced setups?

Hi,
I currently using Wise installer 9 to build setups for my projects but it's very old tool that not support Windows Vista or newer and not UAC aware so I want to buy\use other new installer application that is support all the new Windows stuff and that will be easy to understand and to use.
My projects will contain drivers side and application files and some more advance options so I don't need a small\free tool that cannot support all my needs.
What do you recommend?
Thanks in advance...:wave: