I've spent a lot of hours looking at various Python IDE's, and I've found that they all have their disabilities. However, there is one IDE that has a very similar look and feel to that of Visual Studio. The name is PyScripter, and it can be found here.

Note that this is, IMHO, the "best" IDE out there. It's got a familiar theme, highly configurable, great syntax coloring, and the developer pays very personal attention to each and every bug and feature request. He's already implemented a couple of features I've suggested (and very quickly at that).

Not a lot of people know about PyScripter, so I thought I'd make this post to spread the word a little.