Heard something about...
..it was related to Xp-win2k and servicepaks.
That was:
developing on Xp or on Win2 with later servicepak (ie: sp2), while deploying on a win2k machine with younger servicepak (ie: sp1), could result in an "out of memory" error. Solutions where: upgrade clients to sp2 or downgrade developer machine to sp1...
Not sure it may be related, but it looks like a sort of explanation...
...at present time, using mainly Net 4.0, Vs 2010
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