setup causing problem....

hi....
im trying to create a Setup of my VB.NET application. The problem is ..that once i create the software on one system ...then when i create another setup of the same application on the same system, it gives some reference error.... "like..AsMsFlexGrid.lib...not found..."and such other kinds of reference errors.(probably related to ActiveX components i've used..)
If i change the system and then make the setup then again it works fine for the first time.but if i make some changes in the application and then again create its setup...the reference error again appears..
Is it that once a setup is created ...another setup of the same application is not possible?
Please reply as i urgently need the solution for this problem...
Regards..
Abhishek.