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December 2nd, 2014, 07:54 AM
#1
calculating paternity index of single inconsitency in mutation with python
PYTHON PROGRAMMING CODE TO ASSERTAIN THESE:
person genotype
mother ab
child bc
alleged father de
X = P(man without C will contribute C)
X = P(contributed gene will mutate) * P(mutated gene will be a C)
m = observed rate of mutations/meiosis for the locus
P(mutated gene will be a C) ie. Frequency of C allele = C
X = C * m
For the numerator (X) Probability = 2ab x 2de x 0.5 x m x C
In order to explain this evidence the denominator
must calculate the probability that the paternal allele
is C and a random man would have a genotype
inconsistent with paternity at this locus
Y = P(paternal allele is C and random man has no C allele)
= P(paternal gene is C) * P(random man has no C allele)
P(paternal allele will be a C) ie. Frequency of C allele = C
P(random man has no C allele) = probability of exclusion
Y = C * A
For denominator (Y) Probability = 2ab x 2de x 0.5 x C x A
hence the final result should be:
PI = X/Y
PI = (2ab * 2de * 0.5 * C * m ) / (2ab * 2de * 0.5 * C * A)
PI = m/A
N:B where PI is Paternity Index
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December 3rd, 2014, 09:49 AM
#2
Re: calculating paternity index of single inconsitency in mutation with python
You should post your best attempt first.
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