we have progress, I found that I missed a post from above. My new code is:

modMySql.MySQLQuery = "UPDATE " & modMySql.MySQLDatabase & ".btt SET ScreenShot = ?FileUpload WHERE Ticket=?TN"

modMySql.MySQLConnection.Open()
modMySql.MySQLCommand.CommandText = modMySql.MySQLQuery
modMySql.MySQLCommand.Prepare()
modMySql.MySQLCommand.Parameters.Clear()
modMySql.MySQLCommand.Parameters.Add("?FileUpload", ScreenFile)
modMySql.MySQLCommand.Parameters.Add("?TN", strTicketNo)

My new error is:

+ ex {"Data too long for column 'ScreenShot' at row 52"} System.Exception


Any ideas on this error? Thanks again for all your help.