Thanks for the feedback, but I am looking for a little of both options here. I need to set those variables that are static to the user/machine it is loaded on. And also on seldom changing or very slow moving variables that need to be retained session to session.

The majority of these values will be set when the app is installed so the app.config.file while a nice feature, will not work in my case. The settings options appear to be the best option for my usage.